2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140288
    DBCO-C3-PEG4-amine
    DBCO-C3-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-C3-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-C3-PEG4-amine
  • HY-170351
    NH2-PEG2-OMs
    NH2-PEG2-OMs is the linker, that could be used for synthesis of PROTAC degrader DDC-01-163 (HY-139997).
    NH2-PEG2-OMs
  • HY-140467
    Fmoc-NH-PEG12-CH2COOH 2291257-76-4
    Fmoc-NH-PEG12-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG12-CH2COOH
  • HY-139661
    Boc-bipiperidine-ethynylbenzoic acid 2308497-81-4 99.19%
    Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61. Boc-bipiperidine-ethynylbenzoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-bipiperidine-ethynylbenzoic acid
  • HY-W560922
    Piperazine-Ac-OMe 82516-17-4
    Piperazine-Ac-OMe is a PROTAC linker. Piperazine-Ac-OMe can be used in the synthesis of PROTAC SMARCA2/4-degrader-32 (HY-159459).
    Piperazine-Ac-OMe
  • HY-140795
    Azido-PEG5-Boc 1448451-72-6
    Azido-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-Boc
  • HY-141164
    TCO-PEG36-acid
    TCO-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    TCO-PEG36-acid
  • HY-141252
    N,N-Diethanol amine-PEG4-Boc 2279944-66-8
    N,N-Diethanol amine-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N,N-Diethanol amine-PEG4-Boc
  • HY-172643
    tert-Butyl 2-((5-bromopentyl)oxy)acetate 2571133-90-7
    tert-Butyl 2-((5-bromopentyl)oxy)acetate is a PROTAC linker. tert-Butyl 2-((5-bromopentyl)oxy)acetate can be used in synthesis ERD-308 (HY-128600).
    tert-Butyl 2-((5-bromopentyl)oxy)acetate
  • HY-130198
    DNP-PEG4-acid 858126-76-8
    DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DNP-PEG4-acid
  • HY-138447
    Mal-NH-PEG8-Boc 98.37%
    Mal-NH-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-NH-PEG8-Boc
  • HY-133397
    Azido-PEG15-azide
    Azido-PEG15-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG15-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG15-azide
  • HY-W019795
    m-PEGn-NHS ester 174569-25-6
    m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEGn-NHS ester
  • HY-138493
    F-PEG2-S-Boc
    F-PEG2-S-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    F-PEG2-S-Boc
  • HY-134699
    THP-PEG12-THP
    THP-PEG12-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG12-THP
  • HY-140169
    Carboxy-PEG5-sulfonic acid 1817735-38-8
    Carboxy-PEG5-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Carboxy-PEG5-sulfonic acid
  • HY-156386
    SCO-PEG3-COOH 2141976-36-3
    SCO-PEG3-COOH is a PROTAC linker and belongs to the PEG class. SCO-PEG3-COOH contains SCO and COOH that can be covalently combined with amino groups respectively. SCO is often used to react with amino acid residues of proteins or peptides, particularly lysine.
    SCO-PEG3-COOH
  • HY-140887
    1,1,1-Trifluoroethyl-PEG4-propargyl 1817735-37-7
    1,1,1-Trifluoroethyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    1,1,1-Trifluoroethyl-PEG4-propargyl
  • HY-138366
    Propargyl-PEG11-alcohol 2720615-55-2
    Propargyl-PEG11-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG11-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG11-alcohol
  • HY-130508
    Methyltetrazine-Ph-PEG4-azide 1802908-04-8
    Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Methyltetrazine-Ph-PEG4-azide
PROTAC Linkers Isoform Comparison

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